RAPID COMMUNICATION Does Apolipoprotein(a) Heterogeneity Influence Lipoprotein(a) Effects on Fibrinolysis?
نویسندگان
چکیده
High plasma levels of lipoprotein(a) [Lp(a)] are considered to be an independent risk factor for premature cardiovascular disease and are inversely associated with apolipoprotein(a) [apo(a)] isoform sizes. The contribution of apo(a) polymorphism to the inhibition of fibrinolysis, a mechanism that may favor thrombus development, was therefore evaluated by measuring the ability of Lp(a) particles of distinct apo(a) isoform content to compete with plasminogen for fibrin binding during plasminogen activation by fibrinbound tissue-type plasminogen activator. The rate of plasmin generation was most efficiently inhibited by an isoform with a molecular weight (Mr) of -540 Kd. An isoform with Mr -590 Kd produced a less pronounced effect, whereas the isoform with Mr -610 Kd failed to inhibit
منابع مشابه
Does apolipoprotein(a) heterogeneity influence lipoprotein(a) effects on fibrinolysis?
High plasma levels of lipoprotein(a) [Lp(a)] are considered to be an independent risk factor for premature cardiovascular disease and are inversely associated with apolipoprotein(a) [apo(a)] isoform sizes. The contribution of apo(a) polymorphism to the inhibition of fibrinolysis, a mechanism that may favor thrombus development, was therefore evaluated by measuring the ability of Lp(a) particles...
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